Season 4, Episode 01 – “The Ghost”
In the fourth season premiere, S.H.I.E.L.D. is again legitimatized and gets a new director as Coulson falls back into a roll as an agent and teams up with Mack to track Inhumans. Also: Agent May trains specialist strike teams and Fitz and Simmons take a step forward in their relationship.

Season 4, Episode 02 – “Meet the New Boss”
Daisy battles Ghost Rider, but at a big cost. Also: Coulson faces the new Director, who reveals his bold agenda.

Season 4, Episode 03 – “Uprising”
May fights for her life as her illness worsens and Simmons and Dr. Radcliffe try to save her. Also: Coulson, Mack and Fitz attempt to thwart a rogue group looking to end Inhuman Registration.